Endocrine Abstracts

Background/Introduction: The primary metabolic defect in glycogen storage disease type I (GSDI) results in fasting hypoglycemia and typical secondary metabolic abnormalities (e.g. hypertriglyceridemia, hyperlactatemia, hyperuricemia). The aim of this study was to broadly assess further perturbations of the metabolic network in GSDI by using untargeted plasma metabolomics.Methods: Plasma samples of 14 adult GSDI patients (11 GSDIa, 3 GSDIb. Mean age 26.4&...

Background: Thyroid storm is an extreme disorder that occurs in case of severe thyrotoxicosis. This is a life-threatening condition with mortality rates up to 10–20%. A typical dose of iodinated contrast media (ICM) contains approximately 13.500 µg of free iodide and 15 to 60 g of bound iodine, which represents an acute iodide load of 90 to several hundred thousand times the recommended daily intake of 150 µg. As a result of sudden exposure to high iodide loads...

Introduction: The actual prevalence of early carbohydrate metabolic disorders is associated with persistent hyperglycemia and can only be detected by targeted screening.Objective: We examined 316 people aged 51.21(46.7;62.35) years, without DM.Methods: We determined the 10-year risk of T2DM according to the Findrisc scale, anthropometric data, lipid profile, glycemia and HbA1c level, linear dimensions of preperitoneal and subcuteno...

Introduction: The actual prevalence of early carbohydrate metabolic disorders is associated with persistent hyperglycemia and can only be detected by targeted screening.Objective: We examined 316 people aged 51.21(46.7;62.35) years, without DM.Methods: We determined the 10-year risk of T2DM according to the Findrisc scale, anthropometric data, lipid profile, glycemia and HbA1c level, linear dimensions of preperitoneal and subcuteno...

Introduction: Condition of injected skin and subcutaneous tissue is assessed by visual inspection and palpation and it has only 10–15% diagnostic value. The standard ultrasonography comparison of symmetrical skin areas is not valuable as they are usually used for injections.Objective: We examined 143 patients, aged 43.3 ± 3.9 years, with DM duration of 6.5 ± 2.8 years, receiving basal-bolus insulin therapy.Methods: ...

Mutations in the mitochondrial succinate dehydrogenase (SDH) subunits A, B, C, and D have been shown to hamper oxidative phosphorylation and predispose to pheochromocytomas (PHEOs) and paragangliomas (PGLs). These tumors are characterized by a glycolytic and pseudohypoxic phenotype, which is also seen in most PHEOs/PGLs occurring as part of von Hippel–Lindau (VHL) syndrome, due to VHL gene mutations. The rate of extra-adrenal tumor origin and malignancy however is particu...

A lot of new data have been recently generated regarding the complex relationship between the thyroid function and metabolic parameters.The aim of the study was to estimate the obesity and metabolic syndrome (MS) rates according to the age and the thyroid function in the residents of Belarus.We have examined 894 subjects aged 18–44 years (82.2% females) living in Stolin district, Brest region of Belarus. The endocrinological e...

Aim: To show the etiology of thyromegaly in our region to asses the rationale treatment and follow up.Material and methods: Between 2005 and 2010, we have studied the prevalence and etiologic profile of the children with thyromegaly admitted in the Endocrinology Department of our hospital. The working protocol included: weight and length birth, gestational age, auxological parameters and pubertal stages after Tanner’s criteria, morphogram, laborator...

Aim: To estimate QOL and intensity of depression symptoms in T1DM patients.Materials and methods: Total 53 T1DM patients (26m, 27f), mean age (M±σ) 33.6±2.7 years (20.00–54.00) and 35 of the control group (17m, 18f), mean age 34.8±2.9 years (22.00–50.00) were provided with the questionnaire of Medical Outcomes Study 36-Item Short-Form Health-Survey, Beck depression inventory and Test for estimation of subjective contr...

Tumoral calcinosis is a rare autosomal recessive disease characterized by hyperphosphatemia due to increased renal phosphate reabsorption leading to soft tissue calcifications. The levels of fibroblast growth factor 23 (FGF23), a hormone required for normal renal phosphate reabsorption, are typically low in the classic form of the disease due to homozygous missense mutations in FGF23 or in the UDP-Nacetyl-alpha-D galactosamine:polypeptide N-acetylgalactos...